| Reaction Details |
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 | Report a problem with these data |
| Target | Flap endonuclease 1 |
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| Ligand | BDBM50153254 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1517026 (CHEMBL3619485) |
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| IC50 | 88900±n/a nM |
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| Citation |  Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett25:4104-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Flap endonuclease 1 |
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| Name: | Flap endonuclease 1 |
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| Synonyms: | DNase IV | FEN-1 | FEN1 | FEN1_HUMAN | Flap structure-specific endonuclease 1 | MF1 | Maturation factor 1 | RAD2 | hFEN-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42602.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1517026 |
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| Residue: | 380 |
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| Sequence: | MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGET
TSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAE
QEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDM
DCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRG
IGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSE
PNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEP
KGSTKKKAKTGAAGKFKRGK
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| BDBM50153254 |
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| n/a |
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| Name | BDBM50153254 |
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| Synonyms: | 5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid | 5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid | CHEMBL366051 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8N2O4S |
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| Mol. Mass. | 252.247 |
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| SMILES | Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccs1 |
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| Structure | 
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