Reaction Details |
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Target | Deoxyribonuclease-1 |
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Ligand | BDBM50153250 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1517027 (CHEMBL3619486) |
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IC50 | >100000±n/a nM |
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Citation | Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett25:4104-8 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Deoxyribonuclease-1 |
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Name: | Deoxyribonuclease-1 |
Synonyms: | DNAS1_HUMAN | DNASE1 | DNL1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa |
Type: | PROTEIN |
Mol. Mass.: | 31422.78 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_109543 |
Residue: | 282 |
Sequence: | MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQ
EVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYD
DGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKW
GLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAG
MLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
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BDBM50153250 |
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n/a |
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Name | BDBM50153250 |
Synonyms: | 5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylic Acid | 5,6-dihydroxy-2-(thiophen-2-yl)pyrimidine-4-carboxylic acid | CHEMBL181653 |
Type | Small organic molecule |
Emp. Form. | C9H6N2O4S |
Mol. Mass. | 238.22 |
SMILES | OC(=O)c1nc([nH]c(=O)c1O)-c1cccs1 |
Structure |
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