| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-6 |
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| Ligand | BDBM50123372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1520799 (CHEMBL3625953) |
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| IC50 | 137000±n/a nM |
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| Citation |  Sociali, G; Galeno, L; Parenti, MD; Grozio, A; Bauer, I; Passalacqua, M; Boero, S; Donadini, A; Millo, E; Bellotti, M; Sturla, L; Damonte, P; Puddu, A; Ferroni, C; Varchi, G; Franceschi, C; Ballestrero, A; Poggi, A; Bruzzone, S; Nencioni, A; Del Rio, A Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics. Eur J Med Chem102:530-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-6 |
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| Name: | NAD-dependent protein deacylase sirtuin-6 |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
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| Type: | Protein |
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| Mol. Mass.: | 39133.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N6T7 |
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| Residue: | 355 |
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| Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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| BDBM50123372 |
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| n/a |
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| Name | BDBM50123372 |
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| Synonyms: | CHEMBL3623251 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N3O4S |
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| Mol. Mass. | 393.416 |
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| SMILES | O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccccc1-c1ccccc1 |
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| Structure | 
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