| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50289137 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523464 (CHEMBL3630808) |
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| IC50 | 1460±n/a nM |
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| Citation |  Dounay, AB; Tuttle, JB; Verhoest, PR Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. J Med Chem58:8762-82 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_MOUSE | TO | TRPO | Tdo | Tdo2 | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47757.90 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452150 |
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| Residue: | 406 |
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| Sequence: | MSGCPFAGNSVGYTLKNVSMEDNEEDRAQTGVNRASKGGLIYGNYLQLEKILNAQELQSE
VKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVIARMHRVVV
IFKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHY
RDNFGGDYNELLLKSEQEQTLLQLVEAWLERTPGLEPNGFNFWGKFEKNILKGLEEEFLR
IQAKTDSEEKEEQMAEFRKQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDTLMTKWRYNHVCMVHRMLGTKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLVPRHWVPKMNPIIHKFLYTAEYSDSSYFSSDESD
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| BDBM50289137 |
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| n/a |
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| Name | BDBM50289137 |
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| Synonyms: | 6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indole | CHEMBL355606 | US10155972, Compound 680C91 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11FN2 |
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| Mol. Mass. | 238.2596 |
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| SMILES | Fc1ccc2c(\C=C\c3cccnc3)c[nH]c2c1 |
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| Structure | 
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