Reaction Details |
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Target | DNA gyrase subunit B |
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Ligand | BDBM50126792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1523962 (CHEMBL3630319) |
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IC50 | 44930±n/a nM |
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Citation | Medapi, B; Suryadevara, P; Renuka, J; Sridevi, JP; Yogeeswari, P; Sriram, D 4-Aminoquinoline derivatives as novel Mycobacterium tuberculosis GyrB inhibitors: Structural optimization, synthesis and biological evaluation. Eur J Med Chem103:1-16 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA gyrase subunit B |
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Name: | DNA gyrase subunit B |
Synonyms: | GYRB_MYCSM | gyrB |
Type: | PROTEIN |
Mol. Mass.: | 74505.25 |
Organism: | Mycobacterium smegmatis |
Description: | ChEMBL_107961 |
Residue: | 675 |
Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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BDBM50126792 |
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n/a |
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Name | BDBM50126792 |
Synonyms: | CHEMBL3628445 |
Type | Small organic molecule |
Emp. Form. | C24H30N6O3 |
Mol. Mass. | 450.5334 |
SMILES | COc1ccc2ncc(C(=O)NN)c(Nc3ccc(NCCCN4CCOCC4)cc3)c2c1 |
Structure |
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