| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50126842 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523962 (CHEMBL3630319) |
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| IC50 | 860±n/a nM |
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| Citation |  Medapi, B; Suryadevara, P; Renuka, J; Sridevi, JP; Yogeeswari, P; Sriram, D 4-Aminoquinoline derivatives as novel Mycobacterium tuberculosis GyrB inhibitors: Structural optimization, synthesis and biological evaluation. Eur J Med Chem103:1-16 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | GYRB_MYCSM | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74505.25 |
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| Organism: | Mycobacterium smegmatis |
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| Description: | ChEMBL_107961 |
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| Residue: | 675 |
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| Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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| BDBM50126842 |
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| n/a |
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| Name | BDBM50126842 |
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| Synonyms: | CHEMBL3628523 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N4O4 |
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| Mol. Mass. | 464.5567 |
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| SMILES | CCN1CCN(CCCOc2ccc(Nc3c(cnc4ccc(OC)cc34)C(O)=O)cc2)CC1 |
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| Structure | 
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