| Reaction Details |
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 | Report a problem with these data |
| Target | Estradiol 17-beta-dehydrogenase 1 |
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| Ligand | BDBM50126972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1524166 (CHEMBL3631251) |
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| IC50 | 80±n/a nM |
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| Citation |  Abdelsamie, AS; Bey, E; Gargano, EM; van Koppen, CJ; Empting, M; Frotscher, M Towards the evaluation in an animal disease model: Fluorinated 17ß-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme. Eur J Med Chem103:56-68 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estradiol 17-beta-dehydrogenase 1 |
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| Name: | Estradiol 17-beta-dehydrogenase 1 |
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| Synonyms: | 17-beta-HSD 1 | 17-beta-hydroxysteroid dehydrogenase type 1 | DHB1_RAT | Edh17b1 | Estradiol 17-beta-dehydrogenase 1 | Hsd17b1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36963.81 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_104363 |
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| Residue: | 344 |
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| Sequence: | MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSL
EILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTI
RMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVH
VSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELF
LTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVS
GDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI
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| BDBM50126972 |
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| n/a |
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| Name | BDBM50126972 |
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| Synonyms: | CHEMBL3629586 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H14F5NO5S2 |
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| Mol. Mass. | 555.494 |
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| SMILES | Oc1ccc(F)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F |
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| Structure | 
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