| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50129134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523185 (CHEMBL3632101) |
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| IC50 | 1800±n/a nM |
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| Citation |  Ni, M; Esposito, E; Raj, VP; Muzi, L; Zunino, F; Zuco, V; Cominetti, D; Penco, S; Dal Pozzo, A New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation. Bioorg Med Chem23:6785-93 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50129134 |
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| n/a |
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| Name | BDBM50129134 |
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| Synonyms: | CHEMBL3628322 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H42N6O6S |
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| Mol. Mass. | 626.767 |
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| SMILES | CC(C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)C[C@H](OC(=O)Cn2cc1nn2)\C=C\CCSC(C)=O)C(C)C |r| |
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| Structure | 
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