| Reaction Details |
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 | Report a problem with these data |
| Target | Urease |
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| Ligand | BDBM50129738 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1523760 (CHEMBL3631998) |
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| IC50 | 700±n/a nM |
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| Citation |  Taha, M; Ismail, NH; Imran, S; Wadood, A; Rahim, F; Riaz, M Synthesis of potent urease inhibitors based on disulfide scaffold and their molecular docking studies. Bioorg Med Chem23:7211-8 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease |
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| Name: | Urease |
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| Synonyms: | UREA_CANEN | Urea amidohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 90746.20 |
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| Organism: | Canavalia ensiformis (Jack bean) (Horse bean) |
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| Description: | P07374 |
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| Residue: | 840 |
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| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
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| BDBM50129738 |
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| n/a |
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| Name | BDBM50129738 |
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| Synonyms: | CHEMBL3629545 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20F2N4S4 |
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| Mol. Mass. | 554.721 |
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| SMILES | Fc1ccccc1NC(=S)Nc1ccccc1SSc1ccccc1NC(=S)Nc1ccccc1F |
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| Structure | 
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