| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
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| Ligand | BDBM50129817 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1524104 (CHEMBL3631045) |
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| IC50 | >100000±n/a nM |
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| Citation |  Zhou, ZZ; Ge, BC; Chen, YF; Shi, XD; Yang, XM; Xu, JP Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships. Bioorg Med Chem23:7332-9 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
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| Name: | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
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| Synonyms: | 61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1 |
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| Type: | Protein |
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| Mol. Mass.: | 61245.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54750 |
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| Residue: | 535 |
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| Sequence: | MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
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| BDBM50129817 |
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| n/a |
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| Name | BDBM50129817 |
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| Synonyms: | CHEMBL3628685 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23F2NO4 |
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| Mol. Mass. | 391.4084 |
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| SMILES | COc1ccc(CNC(=O)c2ccc(OC(F)F)c(OC3CCCC3)c2)cc1 |
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| Structure | 
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