| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM50129853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1524126 (CHEMBL3631067) |
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| IC50 | 82160±n/a nM |
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| Citation |  Taha, M; Ismail, NH; Imran, S; Selvaraj, M; Rahim, A; Ali, M; Siddiqui, S; Rahim, F; Khan, KM Synthesis of novel benzohydrazone-oxadiazole hybrids asß-glucuronidase inhibitors and molecular modeling studies. Bioorg Med Chem23:7394-404 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB |
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| Type: | Protein |
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| Mol. Mass.: | 74467.69 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | EC 3.2.1.31, bovine liver |
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| Residue: | 652 |
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| Sequence: | MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGF
EQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRV
VLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHT
LPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQD
IGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYL
YSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSN
VSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVT
FVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSE
YGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVR
MIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
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| BDBM50129853 |
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| n/a |
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| Name | BDBM50129853 |
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| Synonyms: | CHEMBL3628914 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16N4O6 |
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| Mol. Mass. | 432.3856 |
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| SMILES | Oc1cc(O)c(\C=N\NC(=O)c2ccc(cc2)-c2nnc(o2)-c2ccccc2O)c(O)c1 |
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| Structure | 
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