| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM50100997 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1525146 (CHEMBL3635484) |
|---|
| IC50 | 480±n/a nM |
|---|
| Citation |  Gillis, EP; Eastman, KJ; Hill, MD; Donnelly, DJ; Meanwell, NA Applications of Fluorine in Medicinal Chemistry. J Med Chem58:8315-59 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM50100997 |
|---|
| n/a |
|---|
| Name | BDBM50100997 |
|---|
| Synonyms: | 1,1,1-Trifluoro-3-[(3-furan-2-yl-benzyl)-(3-phenoxy-phenyl)-amino]-propan-2-ol | 1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(furan-2-yl)benzyl)amino)propan-2-ol | 3-((3-(furan-2-yl)benzyl)(3-phenoxyphenyl)amino)-1,1,1-trifluoropropan-2-ol | CHEMBL288060 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H22F3NO3 |
|---|
| Mol. Mass. | 453.453 |
|---|
| SMILES | OC(CN(Cc1cccc(c1)-c1ccco1)c1cccc(Oc2ccccc2)c1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
