| Reaction Details |
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 | Report a problem with these data |
| Target | Legumain |
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| Ligand | BDBM50134282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1543634 (CHEMBL3750895) |
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| IC50 | 425±n/a nM |
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| Citation |  Ness, KA; Eddie, SL; Burton, S; Harrison, T; Mullan, P; Williams, R Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors. Bioorg Med Chem Lett26:413-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Legumain |
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| Name: | Legumain |
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| Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
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| Type: | n/a |
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| Mol. Mass.: | 49411.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 433 |
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| Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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| BDBM50134282 |
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| n/a |
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| Name | BDBM50134282 |
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| Synonyms: | CHEMBL3745937 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23ClN4O4S |
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| Mol. Mass. | 462.95 |
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| SMILES | CC(N(Cc1ccc(cc1)-c1cccc(Cl)c1)S(C)(=O)=O)C(=O)N[C@@H](CC(N)=O)C#N |r| |
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| Structure | 
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