| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Fgr |
|---|
| Ligand | BDBM50136226 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1547358 (CHEMBL3757135) |
|---|
| IC50 | 65±n/a nM |
|---|
| Citation |  Yoon, H; Kwak, Y; Choi, S; Cho, H; Kim, ND; Sim, T A Pyrazolo[3,4-d]pyrimidin-4-amine Derivative Containing an Isoxazole Moiety Is a Selective and Potent Inhibitor of RET Gatekeeper Mutants. J Med Chem59:358-73 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Fgr |
|---|
| Name: | Tyrosine-protein kinase Fgr |
|---|
| Synonyms: | FGR | FGR_HUMAN | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC | SRC2 | p55-Fgr | p58-Fgr | p58c-Fgr |
|---|
| Type: | protein |
|---|
| Mol. Mass.: | 59469.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09769 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
|
|
|
|---|
| BDBM50136226 |
|---|
| n/a |
|---|
| Name | BDBM50136226 |
|---|
| Synonyms: | CHEMBL3753341 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N6O |
|---|
| Mol. Mass. | 284.3164 |
|---|
| SMILES | CC(C)n1nc(-c2cc(on2)C2CC2)c2c(N)ncnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
