| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydrofolate reductase |
|---|
| Ligand | BDBM50134784 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1539203 (CHEMBL3739010) |
|---|
| IC50 | 6.4±n/a nM |
|---|
| Citation |  Chao, B; Li, BX; Xiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm6:510-520 (2015) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydrofolate reductase |
|---|
| Name: | Dihydrofolate reductase |
|---|
| Synonyms: | DYR_LACCA | dhfR | folA |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 18437.08 |
|---|
| Organism: | Lactobacillus casei |
|---|
| Description: | ChEMBL_1357878 |
|---|
| Residue: | 163 |
|---|
| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
|
|
|
|---|
| BDBM50134784 |
|---|
| n/a |
|---|
| Name | BDBM50134784 |
|---|
| Synonyms: | CHEMBL526243 | TCMDC-137820 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14N6 |
|---|
| Mol. Mass. | 314.344 |
|---|
| SMILES | Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
