| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50049905 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1539068 (CHEMBL3738284) |
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| Ki | 0.030000±n/a nM |
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| Citation |  Chao, B; Li, BX; Xiao, X The chemistry and pharmacology of privileged pyrroloquinazolines. Medchemcomm6:510-520 (2015) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DFR1 | DYR_CANAX | Dihydrofolate Reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 22141.77 |
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| Organism: | Candida albicans |
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| Description: | C. albicans DHFR was expressed in E. coli BL21, and purified to homogeneity. |
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| Residue: | 192 |
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| Sequence: | MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWE
SIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE
LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEG
DFTYNYTLWTRK
|
|
|
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| BDBM50049905 |
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| n/a |
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| Name | BDBM50049905 |
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| Synonyms: | 7-(1-Ethyl-propyl)-8-methyl-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine | CHEMBL170758 | TCMDC-137283 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H21N5 |
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| Mol. Mass. | 283.3714 |
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| SMILES | CCC(CC)n1c(C)cc2c1ccc1nc(N)nc(N)c21 |
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| Structure | 
|
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