| Reaction Details |
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 | Report a problem with these data |
| Target | Seed linoleate 13S-lipoxygenase-1 |
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| Ligand | BDBM50135284 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1546118 (CHEMBL3749636) |
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| IC50 | 1000±n/a nM |
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| Citation |  Averina, EB; Vasilenko, DA; Gracheva, YA; Grishin, YK; Radchenko, EV; Burmistrov, VV; Butov, GM; Neganova, ME; Serkova, TP; Redkozubova, OM; Shevtsova, EF; Milaeva, ER; Kuznetsova, TS; Zefirov, NS Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents. Bioorg Med Chem24:712-20 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Seed linoleate 13S-lipoxygenase-1 |
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| Name: | Seed linoleate 13S-lipoxygenase-1 |
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| Synonyms: | 15-LOX | 15-Lipo-oxygenase (15-LO) | 15-lipo-oxygenase (SLO) | Arachidonic Acid 15- Lipoxygenase | L-1 | LOX1 | LOX1.1 | LOX1_SOYBN | Lipoxygenase (LOX) | Lipoxygenase (SLO) | Lipoxygenase-1 | Seed lipoxygenase-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 94365.66 |
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| Organism: | Glycine max (soybean) |
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| Description: | n/a |
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| Residue: | 839 |
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| Sequence: | MFSAGHKIKGTVVLMPKNELEVNPDGSAVDNLNAFLGRSVSLQLISATKADAHGKGKVGK
DTFLEGINTSLPTLGAGESAFNIHFEWDGSMGIPGAFYIKNYMQVEFFLKSLTLEAISNQ
GTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAPLVSYREEELKSLRGNGTGERKEY
DRIYDYDVYNDLGNPDKSEKLARPVLGGSSTFPYPRRGRTGRGPTVTDPNTEKQGEVFYV
PRDENLGHLKSKDALEIGTKSLSQIVQPAFESAFDLKSTPIEFHSFQDVHDLYEGGIKLP
RDVISTIIPLPVIKELYRTDGQHILKFPQPHVVQVSQSAWMTDEEFAREMIAGVNPCVIR
GLEEFPPKSNLDPAIYGDQSSKITADSLDLDGYTMDEALGSRRLFMLDYHDIFMPYVRQI
NQLNSAKTYATRTILFLREDGTLKPVAIELSLPHSAGDLSAAVSQVVLPAKEGVESTIWL
LAKAYVIVNDSCYHQLMSHWLNTHAAMEPFVIATHRHLSVLHPIYKLLTPHYRNNMNINA
LARQSLINANGIIETTFLPSKYSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSTPHG
VRLLIEDYPYAADGLEIWAAIKTWVQEYVPLYYARDDDVKNDSELQHWWKEAVEKGHGDL
KDKPWWPKLQTLEDLVEVCLIIIWIASALHAAVNFGQYPYGGLIMNRPTASRRLLPEKGT
PEYEEMINNHEKAYLRTITSKLPTLISLSVIEILSTHASDEVYLGQRDNPHWTSDSKALQ
AFQKFGNKLKEIEEKLVRRNNDPSLQGNRLGPVQLPYTLLYPSSEEGLTFRGIPNSISI
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| BDBM50135284 |
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| n/a |
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| Name | BDBM50135284 |
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| Synonyms: | CHEMBL3746105 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28N2O5 |
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| Mol. Mass. | 376.4467 |
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| SMILES | CC12CC3CC(C)(C1)CC(C3)(C2)OC(=O)c1cc(on1)N(O)C1CCCO1 |TLB:12:9:7.1.2:4,0:1:4:8.9.10,THB:11:1:4:8.9.10,11:9:7.1.2:4,2:1:8:3.4.10,2:3:8:7.1.11,0:1:8:3.4.10| |
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| Structure | 
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