| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Telomeric repeat-binding factor 2-interacting protein 1 |
|---|
| Ligand | BDBM50136305 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1547629 (CHEMBL3755499) |
|---|
| IC50 | 700±n/a nM |
|---|
| Citation |  Ran, X; Liu, L; Yang, CY; Lu, J; Chen, Y; Lei, M; Wang, S Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex. J Med Chem59:328-34 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Telomeric repeat-binding factor 2-interacting protein 1 |
|---|
| Name: | Telomeric repeat-binding factor 2-interacting protein 1 |
|---|
| Synonyms: | DRIP5 | Dopamine receptor-interacting protein 5 | RAP1 | RAP1 homolog | Repressor/activator protein 1 homolog | TE2IP_HUMAN | TERF2-interacting telomeric protein 1 | TERF2IP | TRF2-interacting telomeric protein 1 | hRap1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 44229.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_116704 |
|---|
| Residue: | 399 |
|---|
| Sequence: | MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPG
AVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAE
GAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSL
KDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVK
EEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEE
EEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYP
IWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
|
|
|
|---|
| BDBM50136305 |
|---|
| n/a |
|---|
| Name | BDBM50136305 |
|---|
| Synonyms: | CHEMBL3752828 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C82H138N22O21S2 |
|---|
| Mol. Mass. | 1832.238 |
|---|
| SMILES | CCC(C)C(NC(=O)C(NC(=O)C(NC(C)=O)C(C)O)C(C)O)C(=O)NCC(=O)NC(CCSC)C(=O)NC(CCSC)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC1CCCCn2cc(CC(NC(=O)C(CCCCN)NC(=O)C(Cc3ccccc3)NC(=O)C(C)NC1=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(N)=O)nn2 |
|---|
| Structure | 
|
|---|
Search and Browse
