| Reaction Details |
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 | Report a problem with these data |
| Target | Telomeric repeat-binding factor 2-interacting protein 1 |
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| Ligand | BDBM50136298 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1547629 (CHEMBL3755499) |
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| IC50 | 43300±n/a nM |
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| Citation |  Ran, X; Liu, L; Yang, CY; Lu, J; Chen, Y; Lei, M; Wang, S Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex. J Med Chem59:328-34 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Telomeric repeat-binding factor 2-interacting protein 1 |
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| Name: | Telomeric repeat-binding factor 2-interacting protein 1 |
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| Synonyms: | DRIP5 | Dopamine receptor-interacting protein 5 | RAP1 | RAP1 homolog | Repressor/activator protein 1 homolog | TE2IP_HUMAN | TERF2-interacting telomeric protein 1 | TERF2IP | TRF2-interacting telomeric protein 1 | hRap1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44229.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116704 |
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| Residue: | 399 |
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| Sequence: | MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPG
AVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAE
GAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSL
KDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVK
EEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEE
EEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYP
IWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
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| BDBM50136298 |
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| n/a |
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| Name | BDBM50136298 |
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| Synonyms: | CHEMBL3752820 |
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| Type | Small organic molecule |
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| Emp. Form. | C81H136N22O22S |
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| Mol. Mass. | 1802.146 |
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| SMILES | [H][C@]1(NC(=O)[C@H](CCCCn2cc(C[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(N)=O)nn2)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O |r| |
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| Structure | 
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