| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase B chain |
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| Ligand | BDBM50144758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1555231 (CHEMBL3768757) |
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| IC50 | 220±n/a nM |
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| Citation |  Rani, R; Kumar, V Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. J Med Chem59:487-96 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| L-lactate dehydrogenase B chain |
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| Name: | L-lactate dehydrogenase B chain |
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| Synonyms: | L-lactate dehydrogenase B | L-lactate dehydrogenase B chain | LDH heart subunit | LDH-B | LDH-H | LDHB | LDHB_HUMAN | Lactate dehydrogenase B (LDHB) | Renal carcinoma antigen NY-REN-46 |
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| Type: | Oxidoreductase; homotetramer |
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| Mol. Mass.: | 36635.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 334 |
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| Sequence: | MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLK
GEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKF
IIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLG
IHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAY
EVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARG
LTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
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| BDBM50144758 |
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| n/a |
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| Name | BDBM50144758 |
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| Synonyms: | CHEMBL3765327 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31N5O6S |
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| Mol. Mass. | 589.662 |
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| SMILES | COc1ncc(-c2ccc3c(Nc4cc(cc(c4)C(O)=O)C4CCCC4)c(cnc3c2)S(=O)(=O)NC2CC2)c(OC)n1 |
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| Structure | 
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