| Reaction Details |
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 | Report a problem with these data |
| Target | Mitochondrial sodium/calcium exchanger protein |
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| Ligand | BDBM50139422 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1553171 |
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| IC50 | 1600±n/a nM |
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| Citation |  Martínez-Sanz, FJ; Lajarín-Cuesta, R; González-Lafuente, L; Moreno-Ortega, AJ; Punzón, E; Cano-Abad, MF; de los Ríos, C Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger. Eur J Med Chem109:114-23 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitochondrial sodium/calcium exchanger protein |
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| Name: | Mitochondrial sodium/calcium exchanger protein |
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| Synonyms: | NCKX6 | NCKX6 | NCLX | NCLX_HUMAN | Na(+)/K(+)/Ca(2+)-exchange protein 6 | SLC24A6 | SLC8B1 | Sodium/calcium exchanger protein, mitochondrial | Sodium/potassium/calcium exchanger 6, mitochondrial | Solute carrier family 24 member 6 | Solute carrier family 8 member B1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 64239.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_116727 |
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| Residue: | 584 |
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| Sequence: | MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
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| BDBM50139422 |
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| n/a |
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| Name | BDBM50139422 |
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| Synonyms: | CHEMBL1495071 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11Cl2NOS |
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| Mol. Mass. | 324.225 |
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| SMILES | Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1 |
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| Structure | 
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