| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 2 |
|---|
| Ligand | BDBM50140176 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1547659 (CHEMBL3755710) |
|---|
| IC50 | 6360±n/a nM |
|---|
| Citation |  Ai, T; Qiu, L; Xie, J; Geraghty, RJ; Chen, L Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem24:686-92 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 2 |
|---|
| Name: | Histone deacetylase 2 |
|---|
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
|---|
| Type: | Chromatin regulator; hydrolase; repressor |
|---|
| Mol. Mass.: | 55356.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92769 |
|---|
| Residue: | 488 |
|---|
| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
|
|
|
|---|
| BDBM50140176 |
|---|
| n/a |
|---|
| Name | BDBM50140176 |
|---|
| Synonyms: | CHEMBL3394285 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H8F3NO2 |
|---|
| Mol. Mass. | 231.1712 |
|---|
| SMILES | ONC(=O)\C=C\c1ccc(cc1)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
