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TargetMatrix metalloproteinase-25
LigandBDBM50063917
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1552524
IC50 10000±n/a nM
Citation Ruminski PGMassa MStrohbach JHanau CESchmidt MScholten JAFletcher TRHamper BCCarroll JNShieh HSCaspers NCollins BGrapperhaus MPalmquist KECollins JBaldus JEHitchcock JKleine HPRogers MDMcDonald JMunie GEMessing DMPortolan SWhiteley LOSunyer TSchnute ME Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem 59:313-27 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Matrix metalloproteinase-25
Name:Matrix metalloproteinase-25
Synonyms:Leukolysin | MMP-25 | MT-MMP 6 | MT6-MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase | Membrane-type-6 matrix metalloproteinase (MT6-MMP)
Type:Protein
Mol. Mass.:62564.84
Organism:Homo sapiens (Human)
Description:Q9NPA2
Residue:562
Sequence:
MRLRLRLLALLLLLLAPPARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRD
AIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTL
TWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQ
DSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALG
LGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQ
PPASPTHSPSFPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFW
EGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTELGLPPGEEVDAVF
SWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKG
AHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAA
GRWPAPIPLLLLPLLVGGVASR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50063917
n/a
NameBDBM50063917
Synonyms:(2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide | CHEMBL279785 | cid_119031 | marimastat
TypeSmall organic molecule
Emp. Form.C15H29N3O5
Mol. Mass.331.4079
SMILESCNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: