| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E synthase |
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| Ligand | BDBM50142689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1552594 (CHEMBL3762399) |
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| IC50 | 13840±n/a nM |
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| Citation |  Peduto, A; Krauth, V; Collarile, S; Dehm, F; Ambruosi, M; Belardo, C; Guida, F; Massa, A; Esposito, V; Maione, S; de Rosa, M; Werz, O; Filosa, R Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition. Eur J Med Chem108:466-75 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E synthase |
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| Name: | Prostaglandin E synthase |
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| Synonyms: | MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1) |
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| Type: | Protein |
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| Mol. Mass.: | 17112.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 152 |
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| Sequence: | MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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| BDBM50142689 |
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| n/a |
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| Name | BDBM50142689 |
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| Synonyms: | CHEMBL3759314 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17Cl2NO3S |
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| Mol. Mass. | 446.346 |
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| SMILES | CCOC(=O)c1c(CSc2cc(Cl)cc(Cl)c2)[nH]c2c1cc(O)c1ccccc21 |
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| Structure | 
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