| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-6 receptor subunit beta |
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| Ligand | BDBM50145180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1555122 (CHEMBL3768044) |
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| IC50 | >20000±n/a nM |
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| Citation |  Singh, S; Gajulapati, V; Gajulapati, K; Goo, JI; Park, YH; Jung, HY; Lee, SY; Choi, JH; Kim, YK; Lee, K; Heo, TH; Choi, Y Structure-activity relationship study of a series of novel oxazolidinone derivatives as IL-6 signaling blockers. Bioorg Med Chem Lett26:1282-6 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-6 receptor subunit beta |
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| Name: | Interleukin-6 receptor subunit beta |
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| Synonyms: | CD_antigen=CD130 | CDw130 | IL-6 receptor subunit beta | IL-6R subunit beta | IL-6R-beta | IL-6RB | IL6RB_HUMAN | IL6ST | Interleukin-6 receptor subunit beta | Interleukin-6 signal transducer | Membrane glycoprotein 130 | Oncostatin-M receptor subunit alpha | gp130 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103525.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108130 |
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| Residue: | 918 |
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| Sequence: | MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD
FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT
YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD
QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG
KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK
SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN
TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS
ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV
NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG
MPKSYLPQTVRQGGYMPQ
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| BDBM50145180 |
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| n/a |
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| Name | BDBM50145180 |
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| Synonyms: | CHEMBL3763273 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29NO4 |
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| Mol. Mass. | 359.4593 |
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| SMILES | CCCCCC(=C)[C@@H](O)[C@H](C)C(=O)N1[C@@H](Cc2ccccc2)COC1=O |r| |
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| Structure | 
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