| Reaction Details |
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 | Report a problem with these data |
| Target | Leucine--tRNA ligase, cytoplasmic |
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| Ligand | BDBM50145678 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1556292 (CHEMBL3769291) |
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| IC50 | 115700±n/a nM |
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| Citation |  Gudzera, OI; Golub, AG; Bdzhola, VG; Volynets, GP; Lukashov, SS; Kovalenko, OP; Kriklivyi, IA; Yaremchuk, AD; Starosyla, SA; Yarmoluk, SM; Tukalo, MA Discovery of potent anti-tuberculosis agents targeting leucyl-tRNA synthetase. Bioorg Med Chem24:1023-31 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leucine--tRNA ligase, cytoplasmic |
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| Name: | Leucine--tRNA ligase, cytoplasmic |
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| Synonyms: | KIAA1352 | LARS | LARS1 | Leucyl-tRNA synthetase | SYLC_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 134475.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_98544 |
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| Residue: | 1176 |
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| Sequence: | MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLH
LGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDE
EEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHW
LDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIY
SPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMF
GQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGA
SLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRD
DMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVD
GFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWK
KQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIY
MAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQ
EFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKS
TGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVAN
WDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAV
EGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQ
YLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFE
ANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVL
MENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGH
FSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTP
ISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
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| BDBM50145678 |
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| n/a |
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| Name | BDBM50145678 |
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| Synonyms: | CHEMBL3763921 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13BrN4O4S |
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| Mol. Mass. | 449.279 |
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| SMILES | COc1cc(\C=N/Nc2nc(cs2)-c2ccc(Br)cc2)cc(c1O)[N+]([O-])=O |
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| Structure | 
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