| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50145866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1554117 (CHEMBL3768919) |
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| EC50 | 194±n/a nM |
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| Citation |  Paczal, A; Bálint, B; Wéber, C; Szabó, ZB; Ondi, L; Theret, I; De Ceuninck, F; Bernard, C; Ktorza, A; Perron-Sierra, F; Kotschy, A Structure-Activity Relationship of Azaindole-Based Glucokinase Activators. J Med Chem59:687-706 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50145866 |
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| n/a |
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| Name | BDBM50145866 |
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| Synonyms: | CHEMBL3765780 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClN2O4S |
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| Mol. Mass. | 484.995 |
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| SMILES | COC(=O)\C=C\c1cnc2[nH]c(cc2c1)C(=C/C1CCCC1)\c1ccc(c(Cl)c1)S(C)(=O)=O |
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| Structure | 
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