| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A2, membrane associated |
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| Ligand | BDBM50149981 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1558489 (CHEMBL3773524) |
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| IC50 | 143±n/a nM |
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| Citation |  Vasilakaki, S; Barbayianni, E; Leonis, G; Papadopoulos, MG; Mavromoustakos, T; Gelb, MH; Kokotos, G Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations. Bioorg Med Chem24:1683-95 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A2, membrane associated |
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| Name: | Phospholipase A2, membrane associated |
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| Synonyms: | GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A |
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| Type: | Hydrolase |
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| Mol. Mass.: | 16101.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification. |
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| Residue: | 144 |
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| Sequence: | MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDAT
DRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFAR
NKTTYNKKYQYYSNKHCRGSTPRC
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| BDBM50149981 |
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| n/a |
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| Name | BDBM50149981 |
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| Synonyms: | CHEMBL3769794 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H39NO4 |
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| Mol. Mass. | 369.5387 |
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| SMILES | CCCCCCCCCCCCCCC(=O)C(=O)N[C@@H](C(C)C)C(O)=O |r| |
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| Structure | 
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