Reaction Details |
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Target | Glutaminase kidney isoform, mitochondrial |
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Ligand | BDBM50150658 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1558520 (CHEMBL3773708) |
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IC50 | >5000±n/a nM |
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Citation | McDermott, LA; Iyer, P; Vernetti, L; Rimer, S; Sun, J; Boby, M; Yang, T; Fioravanti, M; O'Neill, J; Wang, L; Drakes, D; Katt, W; Huang, Q; Cerione, R Design and evaluation of novel glutaminase inhibitors. Bioorg Med Chem24:1819-39 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glutaminase kidney isoform, mitochondrial |
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Name: | Glutaminase kidney isoform, mitochondrial |
Synonyms: | GLS | GLS1 | GLSK_HUMAN | Glutaminase 1 | K-glutaminase | KIAA0838 | L-glutamine amidohydrolase |
Type: | Protein |
Mol. Mass.: | 73471.89 |
Organism: | Homo sapiens (Human) |
Description: | O94925 |
Residue: | 669 |
Sequence: | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGG
GGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEG
KELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMD
MLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKK
QSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDL
GTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQ
FLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPA
KSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKL
DPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVE
VVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQT
VHKNLDGLL
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BDBM50150658 |
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n/a |
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Name | BDBM50150658 |
Synonyms: | CHEMBL3769544 |
Type | Small organic molecule |
Emp. Form. | C31H31N5O3 |
Mol. Mass. | 521.6095 |
SMILES | O=C(Cc1ccccc1)Nc1ccc(OC2CCN(CC2)c2ccc(NC(=O)Cc3ccccc3)nc2)nc1 |
Structure |
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