Reaction Details |
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Target | Glycogen phosphorylase, muscle form |
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Ligand | BDBM50150653 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1558648 (CHEMBL3771525) |
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IC50 | 2500±n/a nM |
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Citation | Loughlin, WA; Jenkins, ID; Karis, ND; Schweiker, SS; Healy, PC 2-Oxo-1,2-dihydropyridinyl-3-yl amide-based GPa inhibitors: Design, synthesis and structure-activity relationship study. Eur J Med Chem111:1-14 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen phosphorylase, muscle form |
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Name: | Glycogen phosphorylase, muscle form |
Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
Type: | Enzyme |
Mol. Mass.: | 97296.32 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
Residue: | 843 |
Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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BDBM50150653 |
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n/a |
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Name | BDBM50150653 |
Synonyms: | CHEMBL3770692 |
Type | Small organic molecule |
Emp. Form. | C21H18Cl2N4O4 |
Mol. Mass. | 461.298 |
SMILES | [O-][N+](=O)c1ccc(CNc2cccn(CC(=O)NCc3ccc(Cl)c(Cl)c3)c2=O)cc1 |
Structure |
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