Reaction Details |
| Report a problem with these data |
Target | Cyclin-dependent kinase 4 |
---|
Ligand | BDBM50347389 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1561546 (CHEMBL3776183) |
---|
IC50 | 44700±n/a nM |
---|
Citation | Vymetalová, L; Havlícek, L; ?turc, A; Skrá?ková, Z; Jorda, R; Pospí?il, T; Strnad, M; Kry?tof, V 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases. Eur J Med Chem110:291-301 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cyclin-dependent kinase 4 |
---|
Name: | Cyclin-dependent kinase 4 |
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
Type: | Enzyme Subunit |
Mol. Mass.: | 33731.96 |
Organism: | Homo sapiens (Human) |
Description: | P11802 |
Residue: | 303 |
Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
|
|
|
BDBM50347389 |
---|
n/a |
---|
Name | BDBM50347389 |
Synonyms: | CHEMBL1801932 |
Type | Small organic molecule |
Emp. Form. | C22H32N6 |
Mol. Mass. | 380.5297 |
SMILES | CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 |
Structure |
|