| Reaction Details |
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 | Report a problem with these data |
| Target | Histone lysine demethylase PHF8 |
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| Ligand | BDBM50155509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1565735 |
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| IC50 | <250±n/a nM |
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| Citation |  Abdel-Magid, AF Inhibition of Histone Demethylases Offers a Novel and Promising Approach for the Treatment of Cancer and Other Diseases. ACS Med Chem Lett7:128-30 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone lysine demethylase PHF8 |
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| Name: | Histone lysine demethylase PHF8 |
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| Synonyms: | Histone lysine demethylase PHF8 | Histone lysine demethylase PHF8 (PHF8) | KIAA1111 | Lysine-specific demethylase 7A/7B | PHD finger protein 8 | PHF8 | PHF8_HUMAN | ZNF422 |
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| Type: | Protein |
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| Mol. Mass.: | 117889.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UPP1 |
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| Residue: | 1060 |
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| Sequence: | MNRSRAIVQRGRVLPPPAPLDTTNLAGRRTLQGRAKMASVPVYCLCRLPYDVTRFMIECD
MCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGS
PTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTV
RDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLV
ETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEK
IFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTP
VDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLRE
NRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIF
QQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMSRLSLPSKNGSKKKGLKPKELFKKA
ERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDG
NESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDER
LGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEVEFDIEEDYTTDEDMVEGVEGKLGN
GSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQ
AWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDS
LGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGT
RVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAA
TPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRP
SVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL
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| BDBM50155509 |
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| n/a |
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| Name | BDBM50155509 |
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| Synonyms: | CHEMBL3780689 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N3O3 |
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| Mol. Mass. | 367.4415 |
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| SMILES | C[C@@H](N1CCC[C@H](CNCc2cc(ccn2)C(O)=O)C1=O)c1ccccc1 |r| |
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| Structure | 
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