| Reaction Details |
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 | Report a problem with these data |
| Target | Cellular tumor antigen p53 |
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| Ligand | BDBM188519 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1569637 (CHEMBL3790863) |
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| IC50 | 1500±n/a nM |
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| Citation |  Romero, FA; Taylor, AM; Crawford, TD; Tsui, V; Côté, A; Magnuson, S Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors. J Med Chem59:1271-98 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cellular tumor antigen p53 |
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| Name: | Cellular tumor antigen p53 |
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| Synonyms: | Antigen NY-CO-13 | CREB-binding protein/p53 | GST-p53 | His6-p53 | P53 | P53_HUMAN | Phosphoprotein p53 | TP53 | Tumor Suppressor p53 |
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| Type: | fusion protein |
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| Mol. Mass.: | 43654.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The full-length His6-wt-p53 expressed in E. coli was used in assays. |
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| Residue: | 393 |
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| Sequence: | MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
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| BDBM188519 |
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| n/a |
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| Name | BDBM188519 |
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| Synonyms: | SGC-CBP30 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33ClN4O3 |
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| Mol. Mass. | 509.04 |
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| SMILES | COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl |r| |
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| Structure | 
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