| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50156443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1567918 |
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| IC50 | 8000±n/a nM |
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| Citation |  Kaur, J; Kaur, S; Singh, P Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity. Bioorg Med Chem Lett26:1936-40 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50156443 |
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| n/a |
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| Name | BDBM50156443 |
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| Synonyms: | CHEMBL3785863 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H32Cl4N4O3 |
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| Mol. Mass. | 866.615 |
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| SMILES | OC(Cn1cc(\C=C2/C(=O)N(c3ccccc23)c2c(Cl)cccc2Cl)c2ccccc12)Cn1cc(\C=C2/C(=O)N(c3ccccc23)c2c(Cl)cccc2Cl)c2ccccc12 |
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| Structure | 
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