| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine receptors; D2 & D4 |
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| Ligand | BDBM50157065 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1571915 |
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| Ki | 28±n/a nM |
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| Citation |  Witt JO; McCollum AL; Hurtado MA; Huseman ED; Jeffries DE; Temple KJ; Plumley HC; Blobaum AL; Lindsley CW; Hopkins CR Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists. Bioorg Med Chem Lett 26:2481-8 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dopamine receptors; D2 & D4 |
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| Name: | D2-like dopamine receptor |
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| Synonyms: | D(2C) dopamine receptor | D(4) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | Dopamine D4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 48373.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21917 |
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| Residue: | 467 |
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| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPG
LPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAP
PDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALC
PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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| BDBM50157065 |
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| n/a |
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| Name | BDBM50157065 |
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| Synonyms: | CHEMBL3792907 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21ClN2O3 |
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| Mol. Mass. | 372.845 |
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| SMILES | COc1cc(CN2CCO[C@H](COc3cccc(c3)C#N)C2)ccc1Cl |r| |
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| Structure | 
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