| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol regulatory element-binding protein 2 |
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| Ligand | BDBM50159362 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1567262 (CHEMBL3788940) |
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| IC50 | 17000±n/a nM |
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| Citation |  Vu, CB; Bemis, JE; Benson, E; Bista, P; Carney, D; Fahrner, R; Lee, D; Liu, F; Lonkar, P; Milne, JC; Nichols, AJ; Picarella, D; Shoelson, A; Smith, J; Ting, A; Wensley, A; Yeager, M; Zimmer, M; Jirousek, MR Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid. J Med Chem59:1217-31 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol regulatory element-binding protein 2 |
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| Name: | Sterol regulatory element-binding protein 2 |
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| Synonyms: | BHLHD2 | SRBP2_HUMAN | SREBF2 | SREBP2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123713.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_765690 |
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| Residue: | 1141 |
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| Sequence: | MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGS
GSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTS
VPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQV
LQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVP
VLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILT
TMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT
DAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLK
IEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRS
RILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLL
LWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTC
LAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAK
TSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTA
AMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA
AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEY
LKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT
KVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSG
ATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRR
LAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRER
ATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAA
S
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| BDBM50159362 |
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| n/a |
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| Name | BDBM50159362 |
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| Synonyms: | CHEMBL3785912 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H39N3O2 |
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| Mol. Mass. | 449.6282 |
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| SMILES | CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCNC(=O)c1cccnc1 |
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| Structure | 
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