Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50159789 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1569991 (CHEMBL3789139) |
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Ki | 251±n/a nM |
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Citation | van Loevezijn, A; Venhorst, J; Iwema Bakker, WI; Lange, JH; de Looff, W; Henzen, R; de Vries, J; van de Woestijne, RP; den Hartog, AP; Verhoog, S; van der Neut, MA; de Bruin, NM; Kruse, CG Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket. Bioorg Med Chem Lett26:1605-11 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50159789 |
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n/a |
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Name | BDBM50159789 |
Synonyms: | CHEMBL3785894 |
Type | Small organic molecule |
Emp. Form. | C18H19ClN4O3S |
Mol. Mass. | 406.886 |
SMILES | CCN\C(=N/S(=O)(=O)c1cccc(Cl)c1)N1N=CCC1c1ccc(O)cc1 |c:17| |
Structure |
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