| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Ligand | BDBM50160072 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1565824 (CHEMBL3789431) |
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| IC50 | 245±n/a nM |
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| Citation |  Rutaganira, FU; Fowler, ML; McPhail, JA; Gelman, MA; Nguyen, K; Xiong, A; Dornan, GL; Tavshanjian, B; Glenn, JS; Shokat, KM; Burke, JE Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIß. J Med Chem59:1830-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
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| Synonyms: | BC033004 | PI3K type 3 | PIK3C3 | PK3C3_HUMAN | Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) | Phosphatidylinositol 3-kinase p100 subunit | Phosphoinositide 3-Kinase (PI3K), Vps34 | Phosphoinositide-3-kinase class 3 | PtdIns-3-kinase type 3 | VPS34 | hVPS34 |
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| Type: | Enzyme |
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| Mol. Mass.: | 101551.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human Vps34 protein was expressed as monomeric GST-fusion and purified. |
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| Residue: | 887 |
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| Sequence: | MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVT
CQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAV
PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTK
AHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDG
DESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV
SYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDV
EDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKK
DSQSSVSENVSNSGINSAEIDSSQIITSPLPSVSSPPPASKTKEVPDGENLEQDLCTFLI
SRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRS
LLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVK
IRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRK
ENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNGISAE
VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLN
KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVK
KVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
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| BDBM50160072 |
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| n/a |
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| Name | BDBM50160072 |
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| Synonyms: | CHEMBL3787054 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15ClFN3O3S2 |
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| Mol. Mass. | 439.911 |
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| SMILES | CC(=O)Nc1nc(C)c(s1)-c1ccc(Cl)c(c1)S(=O)(=O)Nc1ccc(F)cc1 |
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| Structure | 
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