| Reaction Details |
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 | Report a problem with these data |
| Target | Nociceptin receptor |
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| Ligand | BDBM50161467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1567395 |
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| IC50 | 21±n/a nM |
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| Citation |  Hayashi, S; Ohashi, K; Mihara, S; Nakata, E; Emoto, C; Ohta, A Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives. Eur J Med Chem114:345-64 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nociceptin receptor |
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| Name: | Nociceptin receptor |
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| Synonyms: | KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40702.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41146 |
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| Residue: | 370 |
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| Sequence: | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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| BDBM50161467 |
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| n/a |
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| Name | BDBM50161467 |
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| Synonyms: | CHEMBL3785560 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27ClN2O |
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| Mol. Mass. | 382.926 |
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| SMILES | Oc1ccc(Cl)c2CC(CN3CCC4(CCc5ccccc45)CC3)NCc12 |
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| Structure | 
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