| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 4E |
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| Ligand | BDBM50163389 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1571728 (CHEMBL3795795) |
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| IC50 | 13000±n/a nM |
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| Citation |  Wu, X; Fang, Z; Yang, B; Zhong, L; Yang, Q; Zhang, C; Huang, S; Xiang, R; Suzuki, T; Li, LL; Yang, SY Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis. Bioorg Med Chem Lett26:2284-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 4E |
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| Name: | Lysine-specific demethylase 4E |
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| Synonyms: | 2-OG-Dependent Histone Demethylase JMJD2E | Histone Lysine Demethylase | Jumonji domain-containing protein 2E (JMJD2E) | KDM4D-like protein | KDM4DL | KDM4E | KDM4E_HUMAN | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E | Lysine-specific demethylase 4E (KDM4E) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56815.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | B2RXH2 |
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| Residue: | 506 |
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| Sequence: | MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMY
DDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQ
RYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLR
HKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDY
GKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRD
DIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLT
LGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLL
MGTRSRAQGHRPQLPLANDLMTNLSL
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| BDBM50163389 |
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| n/a |
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| Name | BDBM50163389 |
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| Synonyms: | CHEMBL3793278 |
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| Type | Small organic molecule |
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| Emp. Form. | C5H6N4O2 |
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| Mol. Mass. | 154.1267 |
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| SMILES | NNc1nccc(n1)C(O)=O |
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| Structure | 
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