| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50164847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1576318 (CHEMBL3801668) |
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| EC50 | 109±n/a nM |
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| Citation |  Zou, MF; Keck, TM; Kumar, V; Donthamsetti, P; Michino, M; Burzynski, C; Schweppe, C; Bonifazi, A; Free, RB; Sibley, DR; Janowsky, A; Shi, L; Javitch, JA; Newman, AH Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity. J Med Chem59:2973-88 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 50647.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14416 |
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| Residue: | 443 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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| BDBM50164847 |
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| n/a |
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| Name | BDBM50164847 |
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| Synonyms: | CHEMBL3799626 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N4O2 |
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| Mol. Mass. | 466.5741 |
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| SMILES | CN(CCCCNC(=O)c1ccc-2c(Cc3ccccc-23)c1)[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23 |r| |
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| Structure | 
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