| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase Mdm2 |
|---|
| Ligand | BDBM50165706 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1574245 (CHEMBL3802428) |
|---|
| IC50 | 2399±n/a nM |
|---|
| Citation |  Tian, Y; Ma, Y; Gibeau, CR; Lahue, BR; Shipps, GW; Strickland, C; Bogen, SL Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors. Bioorg Med Chem Lett26:2735-8 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| E3 ubiquitin-protein ligase Mdm2 |
|---|
| Name: | E3 ubiquitin-protein ligase Mdm2 |
|---|
| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein |
|---|
| Type: | Oncoprotein |
|---|
| Mol. Mass.: | 55196.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00987 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
|
|
|
|---|
| BDBM50165706 |
|---|
| n/a |
|---|
| Name | BDBM50165706 |
|---|
| Synonyms: | CHEMBL3797694 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H33F6N5O4 |
|---|
| Mol. Mass. | 689.6473 |
|---|
| SMILES | CCC[C@H]1N(CCC[C@@]1(Oc1ccc(cc1)C(F)(F)F)C(=O)N1CCC(CC1)Oc1ncccc1C#N)C(=O)c1cnccc1C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
