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TargetTryptophan 5-hydroxylase 1
LigandBDBM50167537
Substrate/Competitorn/a
Meas. Tech.ChEBML_1574259
IC50 11±n/a nM
Citation Goldberg DRDe Lombaert SAiello RBourassa PBarucci NZhang QParalkar VStein AJValentine JZavadoski W Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett 26:2855-2860 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 5-hydroxylase 1
Name:Tryptophan 5-hydroxylase_UNCURATED
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:50990.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1361824
Residue:444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50167537
n/a
NameBDBM50167537
Synonyms:CHEMBL3799498
TypeSmall organic molecule
Emp. Form.C24H28F3N5O3
Mol. Mass.491.506
SMILESN[C@@H](Cc1ccc(cc1)C(=O)\N=C(/N)NCc1c(cccc1C(F)(F)F)N1CCCCC1)C(O)=O |r|
Structure
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