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TargetCaspase-3
LigandBDBM50171507
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1577039 (CHEMBL3807015)
IC50 63200±n/a nM
Citation Deng, CBLi, JLi, LYSun, FJ Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase. Bioorg Med Chem Lett26:3195-201 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Caspase-3
Name:Caspase-3
Synonyms:Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:31607.55
Organism:Homo sapiens (Human)
Description:n/a
Residue:277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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  Blast E-value cutoff:
BDBM50171507
n/a
NameBDBM50171507
Synonyms:CHEMBL3805488
TypeSmall organic molecule
Emp. Form.C22H17ClN4O2
Mol. Mass.404.849
SMILESCN1C(=O)\C(=N/NC(=O)c2ccc(nc2C)-c2ccccc2Cl)c2ccccc12
Structure
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