| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
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| Ligand | BDBM50175285 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580685 (CHEMBL3811131) |
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| Ki | 400±n/a nM |
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| Citation |  Houck, JD; Dawson, TK; Kennedy, AJ; Kharel, Y; Naimon, ND; Field, SD; Lynch, KR; Macdonald, TL Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. ACS Med Chem Lett7:487-92 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 1 |
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| Name: | Sphingosine kinase 1 |
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| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 42521.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYA1 |
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| Residue: | 384 |
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| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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| BDBM50175285 |
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| n/a |
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| Name | BDBM50175285 |
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| Synonyms: | CHEMBL3809605 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H37ClN4O |
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| Mol. Mass. | 433.03 |
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| SMILES | Cl.CCCCCCCCCCCCc1cccc(c1)-c1nc(no1)C1(CC1)C(N)=N |
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| Structure | 
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