| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase TNNI3K |
|---|
| Ligand | BDBM50118418 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1583231 (CHEMBL3816884) |
|---|
| IC50 | 40±n/a nM |
|---|
| Citation |  Lawhorn, BG; Philp, J; Graves, AP; Shewchuk, L; Holt, DA; Gatto, GJ; Kallander, LS GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorg Med Chem Lett26:3355-3358 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase TNNI3K |
|---|
| Name: | Serine/threonine-protein kinase TNNI3K |
|---|
| Synonyms: | CARK | Serine/threonine-protein kinase TNNI3K | TNI3K_HUMAN | TNNI3K |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 92855.14 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_7705748 |
|---|
| Residue: | 835 |
|---|
| Sequence: | MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNL
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
LHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHE
QVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH
FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK
ENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLL
DNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG
GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG
RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQ
YISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDG
HAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT
GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLE
ECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAA
LSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
|
|
|
|---|
| BDBM50118418 |
|---|
| n/a |
|---|
| Name | BDBM50118418 |
|---|
| Synonyms: | CHEMBL3612667 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17N5O2S |
|---|
| Mol. Mass. | 379.436 |
|---|
| SMILES | CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
