| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
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| Ligand | BDBM50178609 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1583243 (CHEMBL3816961) |
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| IC50 | >100000±n/a nM |
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| Citation |  Xi, M; Ge, J; Wang, X; Sun, C; Liu, T; Fang, L; Xiao, Q; Yin, D Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice. Bioorg Med Chem24:3218-30 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 2 |
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| Name: | Sphingosine kinase 2 |
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| Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
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| Type: | Protein |
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| Mol. Mass.: | 69221.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NRA0 |
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| Residue: | 654 |
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| Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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| BDBM50178609 |
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| n/a |
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| Name | BDBM50178609 |
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| Synonyms: | CHEMBL3814952 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N2O4 |
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| Mol. Mass. | 376.4052 |
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| SMILES | COc1cccc(COc2cccc(\C=N\NC(=O)c3ccc(O)cc3)c2)c1 |
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| Structure | 
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