| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 10 |
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| Ligand | BDBM25759 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1584418 (CHEMBL3819961) |
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| IC50 | 24000±n/a nM |
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| Citation |  Vivier, D; Bennis, K; Lesage, F; Ducki, S Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem59:5149-57 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 10 |
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| Name: | Potassium channel subfamily K member 10 |
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| Synonyms: | KCNK10 | KCNKA_HUMAN | Outward rectifying potassium channel protein TREK-2 | Potassium channel subfamily K member 10 | TREK-2 K(+) channel subunit | TREK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59774.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105637 |
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| Residue: | 538 |
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| Sequence: | MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQ
GGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVS
PQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGG
KIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFI
LAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLV
WFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSV
EIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRP
NNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYS
LDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
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| BDBM25759 |
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| n/a |
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| Name | BDBM25759 |
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| Synonyms: | CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucardic | [3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O4 |
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| Mol. Mass. | 406.4742 |
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| SMILES | COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 |
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| Structure | 
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