| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 1 |
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| Ligand | BDBM50180839 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1584573 (CHEMBL3820564) |
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| IC50 | 20±n/a nM |
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| Citation |  Van Dort, ME; Hong, H; Wang, H; Nino, CA; Lombardi, RL; Blanks, AE; Galbán, S; Ross, BD Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K). J Med Chem59:2512-22 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 1 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
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| Synonyms: | MP2K1_MOUSE | Map2k1 | Mek1 | Prkmk1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43474.56 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_506739 |
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| Residue: | 393 |
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| Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
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| BDBM50180839 |
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| n/a |
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| Name | BDBM50180839 |
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| Synonyms: | CHEMBL1998165 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15F3IN3O2 |
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| Mol. Mass. | 465.2089 |
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| SMILES | CNCCONC(=O)c1ccc(F)c(F)c1Nc1ccc(I)cc1F |
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| Structure | 
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