| Reaction Details |
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 | Report a problem with these data |
| Target | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
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| Ligand | BDBM50125760 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1585632 (CHEMBL3820451) |
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| Kd | 4300±n/a nM |
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| Citation |  Dennis, ML; Pitcher, NP; Lee, MD; DeBono, AJ; Wang, ZC; Harjani, JR; Rahmani, R; Cleary, B; Peat, TS; Baell, JB; Swarbrick, JD Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli. J Med Chem59:5248-63 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
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| Name: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase |
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| Synonyms: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase | 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase | HPPK | HPPK_ECOLI | JW0138 | PPPK | folK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18075.55 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | ChEMBL_108237 |
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| Residue: | 159 |
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| Sequence: | MTVAYIAIGSNLASPLEQVNAALKALGDIPESHILTVSSFYRTPPLGPQDQPDYLNAAVA
LETSLAPEELLNHTQRIELQQGRVRKAERWGPRTLDLDIMLFGNEVINTERLTVPHYDMK
NRGFMLWPLFEIAPELVFPDGEMLRQILHTRAFDKLNKW
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| BDBM50125760 |
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| n/a |
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| Name | BDBM50125760 |
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| Synonyms: | 2-Amino-8-(4-chloro-benzylsulfanyl)-1,9-dihydro-purin-6-one | CHEMBL276808 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10ClN5OS |
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| Mol. Mass. | 307.759 |
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| SMILES | Nc1nc2nc(SCc3ccc(Cl)cc3)[nH]c2c(=O)[nH]1 |
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| Structure | 
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